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Global Regenerative Trade

BEAUTY-STEM DUO

Adipose tissue MSCs microfragmentation and purification kit

BEAUTY-STEM DUO is a closed-circuit single-use kit for adipose tissue microfragmentation and purification without any centrifuge and with a minimal manipulation.

The filtering system consistently reduces the adipose clusters providing a highly regenerative lipofilling ideal for aesthetic rejuvenating and revision surgery.

 

The entire processing phase of the liposuctioned tissue occurs inside the device thanks to continuous saline solution washing. This allows to reduce the cellular stress eliminating any traumatic action that may damage the extracellular matrix and its essential trophic and anti-inflammatory function.

The collection and processing bag is equipped with two filters:

  • the first filter microfragments the adipose tissue, while retaining the eventual fibrotic tissue
  • the second filter with a denser mesh retains the microfragmented adipose tissue that is washed with saline solution eliminating all the oily and blood residues which might cause inflammation of the treated tissues.

The final microfragmented and purified product is an autologous adipose tissue with a high regenerative potential indicated for several aesthetic procedures that can easily be injected even through very thin needles.

why us

TIME EFFICIENT

Processes up to 400 ml of adipose tissue in approximatelly 10 minutes. No centrifugation waiting time and machinary clean up. All-in-one system that processes, purifies a high quality lipoaspirate within one device. Ready to use autologous lipofilling.

MINIMAL MANIPULATION

Adipose tissue purification and processing. Preservation of the cells biological properties and maximization of the regenerative potential. Continuous saline solution washing eliminating any traumatic action that may damage the extracellular matrix. Sampling and processing in a sterile closed-circuit environment, eliminating the risk of contamination

EASY

Simple and reproducible technique while mantaining the highest standards for fat grafting. Compared to centrifugation, BEAUTY-STEM minimizes staff training, OR preparation and clean-up. Allows to repeat the procedure with the same kit on the same patient Multiple waste bag connection for large volume liposuction.

CONVENIENT

No centrifugation required. Single surgical time and day hospital procedure. Only 1 operator required. No machinery loan and maintenance.

Fast growing company

Engaged in developing

Innovative solutions

MEDICAL PROFESSIONALS

BEAUTY-STEM DUO is a closed-circuit single-use kit for adipose tissue microfragmentation and purification without any centrifuge and with a minimal manipulation.

TEAR TROUGH CORRECTION

DEEP FOLD VOLUMIZATION

FINE WRINKLES CORRECTION

FULL FACIAL REGENERATION 

RADIOTHERAPY DYSTROPHIC SKIN (BREAST)

POST BURN SCARS

ULCERS RECONSTRUCTION

CHRONIC ULCERS REGENERATION

SURGICAL TECHNIQUE​

1.Infiltrate the Klein solution in the selected harvest site.

  1. Harvest the adipose tissue from the previously infiltrated area.
  2. Connect a saline bag to the device’s “WASH IN” valve and open the clamp to fill the device.
  3. Insert the harvested adipose tissue in the device’s “LIPO IN” valve.
  4. Support the purification of the adipose tissue using the spatula provided with the kit, with a gentle movement on the filter and without exerting any pressure.
  5. Once the final product acquires a clear yellow color, stop the saline solution flow.
  6. Retrieve the purified adipose tissue from the dedicated “LIPO OUT” valve with a syringe and use as needed.

SURGICAL TECHNIQUE

1. Infiltrate the Klein solution in the elected harvest site using the 16 G Klein cannula

2. Harvest the adipose tissue from the anesthetized area using the 13 G lipoaspiration cannula.

3. Connect a 2L saline bag to the device’s “WASH IN” valve and fill the device.

4. Insert the harvested adipose tissue in the device’s “LIPO IN” valve.

5. The collection and processing bag is equipped with two filters: the first filter microfragments the adipose tissue, while retaining the eventual fibrotic tissue.

6. Support the purification of the adipose tissue using the processing spatula. This will gently microfragment and purify the adipose tissue.

 

7. The second filter with a denser mesh retains the microfragmented adipose tissue and discharges the pro-inflammatory contents and liquids in the waste bag.

8. The eventual fibrotic tissue is retained in the first filter, allowing to obtain a high qualitative adipose tissue.

9. Continue to gently move the processing spatula on the filter to facilitate the complete washing of the tissue.

 

Once the final product acquires a clear yellow color, stop the saline solution flow and gently remove the excess of water using the processing spatula.

 

10. With the help of the processing spatula retrieve the purified and microfragmented adipose tissue from the dedicated “LIPO OUT” valve and use as needed.

– BEAUTY-STEM DUO device

The device is supplied ready-to-use with a 400 ml capacity processing bag and a 2 lt waste collecting bag. The kit includes a processing spatula to facilitate the tissue purification.

The system has 3 valves:

       – WASH IN: to connect the saline solution

      – LIPO IN: to transfer the harvested adipose tissue into the device

      – LIPO OUT: to extract the microfragmented and purified adipose tissue.

 

 

– Filtering system

The sophisticated filtering system inside the processing and filtering bag is equipped with two filters:

  • the first filter microfragments the adipose tissue, while retaining the eventual fibrotic tissue
  • the second filter with denser mesh retains the reduced (microfragmented) adipose tissue that is washed with saline solution eliminating all the oily and blood residues which might cause inflammation of the treated tissues. 

60 ml Klein solution syringe

60 ml Vaclok syringe for lipo-aspiration

Videos for you!

SUPPORTING EVIDENCE

GYNECOLOGY

 

Microfractured and Purified Adipose Tissue (LipogemsTM system) Injections for Treatment of Atrophic Vaginitis
Jennifer Fantasia, Halland Chen, and Janice A. Santos Cortes
J Urol Res 3(7): 1073.

Autologous adipose tissue graft in the vulva in severe vulvar lichen sclerosus atrophicus: clinical case
Davide De Vita, Carmen Sciorio, Serena Spartano
September 2016 – Vol. 28 – N. 5 – Supplement – Quarterly – ISSN 2385 – 0868

Menopause: new frontiers in the treatment of urogenital atrophy
G.A. Casarotti, P. Chiodera, C. Tremolada
European Review for Medical and Pharmacological Sciences 2018; 22: 567-574

 

 

BASIC SCIENCE

 

Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue

Sara Nava, Valeria Sordi, Luisa Pascucci, Carlo Tremolada, Emilio Ciusani, Offer Zeira, Moris Cadei, Gianni Soldati, Augusto Pessina,
Eugenio Parati, Mark Slevin and Giulio Alessandri
Hindawi
Stem Cells International
Volume 2019, Article ID 5901479, 13 pages
https://doi.org/10.1155/2019/5901479

A New Nonenzymatic Method and Device to Obtain a Fat Tissue Derivative Highly Enriched in Pericyte-Like Elements by Mild Mechanical Forces from Human Lipoaspirates
Francesca Bianchi, Margherita Maioli, Erika Leonardi,§ Elena Olivi, Gianandrea Pasquinelli, Sabrina Valente, Armando J. Mendez,
Camillo Ricordi, Mirco Raffaini, Carlo Tremolada and Carlo Ventura
Cell Transplantation, Vol. 22, pp. 2063–2077, 2013

Lipogems, a New Modality of Fat Tissue Handling to Enhance Tissue Repair in Chronic Hind Limb Ischemia
F. Bianchi, E. Olivi, M. Baldassarre, F.A. Giannone, M. Lagge-a, S. Valente, C. Cavallini, R. Tassinari, S. Canaider, G. Pasquinelli, C.
Tremolada, C. Ventura
CellR4 2014; 2 (6): e1289

Human Lipoaspirate as Autologous Injectable Active Scaffold for One-Step Repair of Cartilage Defects
Michela Bosetti, Alessia Borrone, Antonia Follenzi, Fanuel Messaggio, Carlo Tremolada and Mario Cannas
Cell Transplantation, Vol. 25, pp. 1043–1056, 2016

Characteristics and Properties of Mesenchymal Stem Cells Derived from Microfragmented Adipose Tissue
Stephana Carelli, Fanuel Messaggio, Alessandra Canazza, Danuta Maria Hebda, Filippo Caremoli, Elisa Latorre, Maria Grazia
Grimoldi, Mattia Colli, Gaetano Bulfamante, Carlo Tremolada, Anna Maria Di Giulio and Alfredo Gorio
Cell Transplantation, Vol. 24, pp. 1233–1252, 2015

 

Vivostat Logo

THE VIVOSTAT® SYSTEM

The uniqueness of the Vivostat® system is a novel patented biotechnological process that enables reliable and reproducible preparation of autologous Fibrin Sealant or Platelet Rich Fibrin (PRF®) without using cryoprecipitation and without the need for a separate thrombin component.

THE FULLY AUTOMATED VIVOSTAT® SYSTEM CONSISTS OF THREE COMPONENTS: