Global Regenerative Trade



During the design and production of the product, it was ensured that the interconnected pore structure, in which the bone cells can be placed, is considered.


Bones are living tissue and constantly changing. During childhood, bones are primarily developing and strengthening.  However, as we age some of our bone cells begin to dissolve bone matrix (resorption), while new bone cells deposit osteoid (formation). This process is known as remodeling. Disruption of this remodeling cycle and any resulting imbalance between bone resorption and formation leads to metabolic bone disease, most commonly osteoporosis.

Artificial bone tissue is used to strengthen the bone formation in osteoporosis disease. Bone tissue is controlled by the blood-based regulators, the physical environment, the neural network surrounding the periosteum, and the genetic structure of the person. Developed artificial bone tissue is designed to allow this control.

The balance between formation and resorption is called homeostasis. It can be assumed that formation and resorption has completely renewed in about 4 to 10 years depending on the size of the bone. Unlike other tissues and organs, bone tissue repair is like a form of self-renewal, which is called regeneration. The regeneration and repair does not occur without blood circulation.

Therefore, the product is designed to allow renewal of bone and blood circulation as pore diameter and total porosity.

Artificial bone tissue shaped according to the place where it will be used can vary from dust and particles to structural blocks that represent the long bone or spine. Besides the material properties of the bone tissue, its hierarchical structure also affects its mechanical properties.

The graft materials used have one or more of osseointegration, osteogenesis, osteoconductive or osteoinductive properties.

TCP is dissolved and resorbed faster than hydroxyapatite frequently used in graft materials. Since the pore structure is very small and there is no connection between the pores, bone cells cannot progress into the structure without resorption. Therefore, the granular form of TCP is more useful as a bone graft.

New bone formation is faster in bioceramics with pore diameter 300-600 micrometer. As the pore diameter increases, mechanical strength decreases despite the acceleration of new bone production. It is known that human spongiform bone is 85% porous, 70-95% of its pores are connected to each other and respond to the direction of construction under physiological loads.

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The uniqueness of the Vivostat® system is a novel patented biotechnological process that enables reliable and reproducible preparation of autologous Fibrin Sealant or Platelet Rich Fibrin (PRF®) without using cryoprecipitation and without the need for a separate thrombin component.