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The world’s only system for on-site preparation of autologous fibrin sealant and Platelet Rich Fibrin (PRF®). It provides a range of safe, versatile and user-friendly products for a great number of clinical applications.
The uniqueness of the Vivostat® system is a novel patented biotechnological process that enables reliable and reproducible preparation of autologous Fibrin Sealant or Platelet Rich Fibrin (PRF®) without using cryoprecipitation and without the need for a separate thrombin component.
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1Besides the Spraypen®, the Vivostat® system offers different types of applicators, e.g. the Endoscopic Applicator. For a full list of application devices click here
Unlike conventional application systems, the Vivostat® Spraypen gives the surgeon freedom to place the solution very accurately on the target site instead of the surrounding tissue. This is especially important in pin point applications, micro anastomosis and difficult to reach areas.
The great degree of accuracy enables the surgeon to make better use of the fibrin sealant/PRF® solution and improves efficiency.
The single-use endoscopic application catheter is easily loaded into the endoscopic applicator handle (reusable) and the handle is inserted via a 5 mm trocar.
When using the Endoscopic Applicator, the Vivostat® solution is applied through the same unique nozzle that is also used with the Spraypen®. This allows the surgeon to apply the Vivostat® solution in a precise and targeted manner throughout the entire procedure without experiencing blockage. Due to the preformed nozzle, the spray tip can easily be manipulated in many directions giving the surgeon unparalleled freedom in control of application, unobtainable with conventional application systems.
When using the Vivostat® Endoscopic Applicator the application of fibrin or PRF® is activated by a foot switch.
However, there is an additional channel in the catheter that allows the surgeon to co-deliver a substance together with the Vivostat Fibrin Sealant or Patelet Rich Fibrin (PRF®).
With the Endoscopic Kit – Co-delivery the surgeon is able to topically co-apply the substance, for slow release from the Vivostat Fibrin Sealant or PRF® solutions. Doing this endoscopically means less stress on the patient.
When using The Vivostat® Endoscopic Straight the fibrin sealant or PRF® solution is applied through the same unique nozzle that is also used with the Vivostat® Spraypen®. This allows the surgeon to apply the Vivostat® solution in a precise and targeted manner throughout the entire procedure without experiencing blockage. When using the Vivostat® Endoscopic Straight the application of fibrin or PRF® is activated by a foot switch.
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The thrombocyte solution used in these cases has traditionally been supplied by the blood bank.
Recently, a number of commercial products have entered the market with simpler and smaller devices that are still based on the same centrifugation technology. Most products still require sterile handling and have shortcomings in both the biophysical properties and the delivery system.
Vivostat has solved these problems by leveraging the revolutionary technology used in the Vivostat® system for the preparation and application of autologous fibrin sealant. By combining a fibrin sealant solution with a platelet concentrate, it is possible
to have a carrier, a controlled release and a medium for vascular ingrowth
– all in one product, Vivostat PRF® (Platelet Rich Fibrin).
Using the Vivostat® system, you can prepare autologous platelets with multiple growth factors embedded in a fibrin sealant matrix. From 120 ml blood, 5-6 ml of Platelet Rich Fibrin (PRF®) is prepared. By combining a platelet concentrate with a fibrin sealant solution, it is possible to have a carrier, a controlled release and a medium for vascular ingrowth – all in one product, Vivostat PRF®. Compared to conventional PRP products, Vivostat PRF® has a number of advantages.
With an average 7-fold increase over baseline blood levels, the platelet concentration in Vivostat PRF® exceeds the baseline platelet count of 1 million/μL, which has become a benchmark within platelet therapy. The fibrin matrix ensures a slow release of growth factors over time and effectively protects the growth factors against proteolytic degradation.
The specially designed Vivostat® Spraypen® and the unique combination of platelets and fibrin ensures easy, accurate and efficient application of Vivostat PRF®. Due to instant polymerisation and excellent adhesive properties of the fibrin component, the PRF® solution remains where it is applied – even when applied on vertical or inverted surfaces. As the fibrin component in Vivostat PRF® is based on a fibrin 1 solution, there is no need to use a separate thrombin component.
The Vivostat® system is the first and only system on the market to offer a convenient and fully automated process for the preparation of a platelet rich fibrin (PRF®).
Vivostat PRF® contains a variety of potent growth factors that stimulate fibroblast proliferation and tissue synthesis, e.g. TGF-β1,PDGF, VEGF, FGF-2 etc. Several in-vitro investigations confirm the unique characteristics of Vivostat PRF® and its ability to stimulate cell growth.
Apart from producing structural proteins such as collagen, they stimulate both angiogenesis and epithelialisation.
In-vitro studies have proven the positive effect of Vivostat PRF® on fibroblast proliferation. As illustrated, Vivostat PRF® increases the growth of normal human skin fibroblasts compared to control and performs significantly better than PDGF-BB (commercial growth factor).
Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin, Lundquist R. et al., Wound Repair and Regeneration 2008; 16(3): 356-63
In-vitro studies have illustrated the positive effect of Vivostat PRF® on the ability of fibroblasts to synthesise collagen. Vivostat PRF® performs better than PDGF-AB, the major PDGF isoform in human platelets. The reason for this may be that Vivostat PRF® contains multiple growth factors and not just PDGF-AB.
Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin, Lundquist R. et al., Wound Repair and Regeneration 2008; 16(3): 356-63
Controlling the release of platelet contents over several days requires not only a delivery media but also protection of the platelets against degradation.
The autologous fibrin matrix in Vivostat PRF® has shown to protect endogenous growth factors against proteolytic degradation and thereby preserve their biological activity.
Bioactivity and stability of endogenous fibrogenic factors in platelet-rich fibrin, Lundquist R. et al., Wound Repair and Regeneration 2008; 16(3): 356-63
Following application of the Vivostat PRF® solution, the fibrin matrix will naturally be broken down by fibrinolytic processes (fibrinolysis), and during this process the growth factors contained in the platelets are gradually released to the treatment site over a period of 4 days or more. In effect, the fibrin matrix is a delivery media that slowly releases growth factors over time.
Vivostat offers the surgeon a choice of two products which can help overcome these challenges. If haemostasis, sealing or gluing are the primary challenges, Vivostat® Fibrin Sealant is an excellent choice. If it is a combination of haemostasis, sealing, gluing and regeneration of tissue, Vivostat PRF® is the ideal product.
Vivostat Autologous Fibrin Sealant is an autologous sealant that outperforms other fibrin sealants on parameters such as polymerisation, elasticity, adhesion and impact on tissue.
Vivostat PRF® is a second generation platelet enriched product acting both as a haemostat/sealant while at the same time supporting tissue regeneration and wound healing.
Mesh Fixation with Autologous Platelet-Rich Fibrin Sealant in Inguinal Hernia Repair
I.H.J.T. de Hingh, S.W. Nienhuijs, E.P. Overdevest, K. Scheele, P.A.M. Everts
European Surgical Research 2009; 43: 306–309
Experimental study of a novel fibrin sealant for achieving haemostasis following partial hepatectomy
B.R. Davidson, S. Burnett, M.S. Javed, A. Seifalian, D. Moore, N. Doctor
British Journal of Surgery 2000; 87: 790-795
Laparoskopische Eingriffe an der Milz
S. Uranüs, J. Pfeifer, O. Alimoglu, T. Hzmen
Chirurgische Gastro enterologie 2004; 20 (2):35–41
Autologous fibrin sealant (Vivostat) for mesh fixation in laparoscopic transabdominal preperitoneal hernia repair
Schmidt SC, Langrehr JM
Endoscopy 2006; 38:841 – 844
Laparoscopy in Abdominal Trauma
S. Uranüs, K. Dorr
European Journal of Trauma and Emergency Surgery 2010; 36: 19–24
Platelet-Rich Fibrin Sealant as a Treatment for Complex Perianal Fistulas: A Multicentre Study
F.J Pérez Lara et. al.
The Society for Surgery of the Alimentary Tract. 2014
Using autologous platelet-rich plasma for the treatment of complex fistulas
Moreno-Serrano et. al.
Revista Española de Enfermedades Digestivas 2016; Vol 108, 123-128
Liver surgery – Anatomical left lateral sectoriectomy from Vivostat A/S on Vimeo.
Distal Pancreatectomy from Vivostat A/S on Vimeo.
Laparoscopic hernia repair from Vivostat A/S on Vimeo.
The high concentration of fibrin found in Vivostat PRF®, furthermore, acts as a glue enabling the surgeon to use Vivostat PRF® for graft fixations. Using Vivostat PRF® to fixate the graft allows the surgeon to use less staples or none at all depending on the location of the burn. The fibrin also acts as a haemostatic reducing the risk of haematoma formation, which may cause graft loss. Any remaining Vivostat PRF® can be applied to the graft harvest site to speed up tissue regeneration and reduce pain for the patient.
Skin cells/stem cells are expensive and it is crucial that they do not run off the burn or stick to the dressing. By using the Vivostat® system it is possible to glue the skin cells/stem cells to the burn with the Vivostat PRF® solution.
PRF® solution ensures that the cells stay where they are applied as the fibrin found in Vivostat PRF® polymerizes upon application.
Evaluation of platelet-rich fibrin in deep dermal burn: a case study
Fontein D., Burger M., Mannil L., Giovanoli P., Plock J.
Abstract presented at 53. Congress of Swiss Plastic Surgery
Succesful application of keratinocyte suspension usin autologous fibrin spray
Johnstone P., Kwei J.S., Filobbos G., Lewis D., Jeffery S.
Journal of the International Society for Burn Injuries
Burns surgery from Vivostat A/S on Vimeo.
Vivostat® offers the surgeon a choice of two products that can help with the above challenges. If haemostasis and/or sealing are the primary challenges, Vivostat® Fibrin Sealant is an excellent choice. If the primary challenge is tissue regeneration, Vivostat PRF® is the best choice
Vivostat Autologous Fibrin Sealant is an autologous sealant that outperforms other fibrin sealants on parameters such as polymerisation, elasticity, adhesion and impact on tissue.
Vivostat PRF® is a second generation platelet enriched product acting both as a haemostat/sealant while at the same time supporting tissue regeneration and wound healing.
Application of Platelet Rich Fibrin to prevent infection in the implantation of HeartWare®-LVAD-system
R. -U. Kühnel, T. Müller, M. Hartrumpf, M. Erb, J. M. Albes
Kardiotechnik 2013: 22(2):43-45
Use of topical heamoatatic agents to control perioperative bleeding in cardiac surgery
P. Nardi et al.
Presented at The Onassis Cardiac Surgery Center, September 2010
Minimally invasive Ross procedure through partial upper sternotomy
U. F.W. Franke, M. Albert, C. Rustenbach and H. Baumbach
Interact CardioVasc Thorac Surg 2009;9:545-546
Important steps to avoid tamponade in minimally invasive aortic valve replacement
S. Foghsgaard, H. K. Kjaergard
Department of Cardiothoracic Surgery, Gentofte Hospital, Denmark
A Comparison of the Haemostatic Effect of Vivostat Patient Derived Fibrin Sealant
J. B. Hanks, H. K. Kjaergard, D. A. Hollingsbee
European Surgical Research 2003; 35: 439-444
Vivostat System Autologous Fibrin Sealant
H. K. Kjaergard, H. R.Trumbull
The Annals of Thoracic Surgery 1998; 66: 482-486
Application of platelet rich fibrin for infection prophylaxis during implantation of HeartWare® LVAD systems
R.-U. Kuehnel, T. Mueller, L. Romeike, M. Erb, J.M. Albes
Immanuel Klinikum Bernau Herzzentrum Brandenburg, Abteilung für Herzchirurgie, 2014
Topical use of autologous fibrin glue in high-risk CASG patients
D. Wiedemann, D. Vill, N. Bonaros, G. Laufer, T. Schachner, A. Kocher
European surgery 2011:43/5: 309-314
The laparoscopically harvested omental flap for deep sternal wound infection
J. Wingerden, M. Coret, C. Nieuwenhoven, E. Totté
European Journal Cardiothorac Surgery 2010; 37: 87-92
Bleeding from the sternal marrow can be stopped using Vivostat® patient-derived fibrin sealant
H. K. Kjaergard, H. R.Trumbull
The Annals of Thoracic Surgery 2000; 69: 1173-1175
The combination of vacuum therapy and Platelet Rich Fibrin – a new option in the treatment of mediastinitis
R.-U. Kuehnel, L.Michera, G.Loladze, Y. Kuhn, J. Albes
Presented at the Deutsche Gesellschaft für Wundheilung und Wundbehandlung congress 2012
Autologous Platelet Rich Fibrin PRF® using Growth Factores as a new Therapeutic Option for Sternal Wound Healing
Kuehnel R.U. et al.
Presented at World Society of Cardiothoracic Surgery 2011
Successful use of Platelet Rich Fibrin therapy (PRF) in post-operative cardiac surgical infected wounds: first reported case series
Datta, Subir
EACTS Daily News 2016; Issue 2
Vivostat Fibrin Sealant applied on the Aortic Root from Vivostat A/S on Vimeo.
Aortic valve / by-pass procedure from Vivostat A/S on Vimeo.
One of the main challenges in neurosurgery is cerebrospinal fluid (CSF) leakage. Infections are another challenge. The risk of infections increases due to “dead spaces”. It is therefore preferable to fill
these with a sterile and autologous product.
Vivostat® offers the surgeon a choice of two products, which can help
overcome these challenges. If sealing, gluing and/or haemostasis
are the primary challenges, Vivostat® Fibrin Sealant is an excellent
choice. If it is a combination of sealing, gluing, haemostasis and regeneration
of tissue, Vivostat PRF® is the ideal solution.
Vivostat Autologous Fibrin Sealant is an autologous sealant that
outperforms other fibrin sealants on parameters such as polymerisation,
elasticity, adhesion and impact on tissue.
Vivostat PRF® is a second generation platelet enriched product acting
both as a haemostat/sealant while at the same time supporting tissue
regeneration and wound healing.
Use of fibrin sealant (Vivostat®) in skull base surgery
P.M. Baptista, S. Fernández, B. Bejarano, R. Manrique
University of Navarra, the ENT and Neuro Department, Navarra, Spain
A safety study of the use of Vivostat® patient-derived fibrin sealant containing tranexamic acid in neurosurgery
L. Poulsgaard, A. Mørck, N.E. Holm
Presented at 18th Annual Meeting of the North American Skull Base Society 2007
Use of autologous fibrin adhesive in neurosurgery
D. Bovenzi et al
Presented at SIDEM (Società Italiano di Emaferesi e Manipollazione Cellulare) 2007
Using an Autologous Fibrin Sealant in the Preventing of Cerebrospinal Fluid Leak with Large Skull Base Defect Following Endoscopic Endonasal Transsphenoidal Surgery
Yildirim AE. et al
Turkish Neurosurgery 2013, Vol: 23, No: 6, 736-741
Autologous fibrin sealant (Vivostat®) in the neurosurgical practice: Part I: Intracranial surgical procedure
Graziano, et al
Surgical Neurology International 2015, 6:77.
Aulogous fibrin sealant (Vivostat®) in the neurosurgical practice: Part II: Vertebro-spinal procedures
Graziano. et al
Surgical Neurology International 2016, Vol: 7, Suppl 3
Vivostat: an autologous fibrin sealant as useful adjunct in endoscopic transnasal CSF-leak repair
Tomazic et. al.
Department of General Otorhinolaryngology, Head and Neck Surgery, ENT-University Hospital Graz, 2014
Preventing CSF leaks with Vivostat Fibrin Sealant from Vivostat A/S on Vimeo.
Acoustic neuroma – translabyrinthine approach from Vivostat A/S on Vimeo.
Vivostat offers the surgeon a choice of two products which can help overcome these challenges. If achieving haemostasis is the primary goal, Vivostat® Fibrin Sealant is an excellent choice. If the primary challenge is connective tissue regeneration, Vivostat PRF® is the best choice.
Vivostat Autologous Fibrin Sealant is an autologous sealant that outperforms other fibrin
sealants on parameters such as polymerisation, elasticity, adhesion and impact on tissue.
Vivostat PRF® is a second generation platelet enriched product acting both as a
haemostat/sealant while at the same time supporting tissue regeneration and wound healing.
1: The biology of platelet-rich plasma and its application in trauma and orthopaedic surgery · Alsousou J et al. · J Bone Joint S. 2009;91-B:987-96
2: Fibrin sealant use for minimising peri-operative allogeneic blood transfusion · Carless P. et al. · Cochrane Database of Systematic Reviews · July 2009
Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: From open field autologous chondrocyte to bone-marrow-derived cells transplantation
S. Giannini, R. Buda, M. Cavallo, A. Ruffilli, A. Cenacchi, C. Cavallo, F. Vannini
Injury: International Journal of Care of the Injured 2010; 41: 1196–1203
Use of autologous bone marrow cells concentrate enriched with platelet-rich fibrin on corticocancellous bone allograft for posterolateral multilevel cervical fusion
G. Vadalà, A. Di Martino, M. C. Tirindelli, L. Denaro, V. Denaro
Journal of Tissue Engineering and regenerative Medicine 2008; 2: 515–520
Femoroacetabular Osteoplasty by means of anterior mini open approach combined with arthroscopy. Surgical Technique and results at a minimum followup of 4 years
V. Bellotti et al.
GIOT Febbraio 2013;39:30-38
Knee surgeons at London Bridge Hospital get stuck into the use of Biological glues
London Bridge Hospital
Health Matters 2016; Issue 18, p.11
Cartilage repair – Chrondrotissue graft and Vivostat PRF from Vivostat A/S on Vimeo.
Vivostat PRF used for meniscal repair from Vivostat A/S on Vimeo.
Vivostat PRF in Total Knee Replacement – Orthopaedic Surgery from Vivostat A/S on Vimeo.
Vivostat PRF in Total Hip Replacement from Vivostat A/S on Vimeo.
Medial epicondylitis – Golfer’s Elbow HD from Vivostat A/S on Vimeo.
Vivostat PRF – Meniscal transplant from Vivostat A/S on Vimeo.
An added benefit of the Vivostat®system is the option of applying the special Endoscopic Applicator When using the Endoscopic Applicator, Vivostat® Fibrin Sealant is applied through the same unique nozzle as is the case with the Spraypen®. Due to the pre-bent nozzle, the spray tip can easily be pointed in many directions, offering the surgeon freedom of control of the application, which is not obtainable with conventional systems.
A prospective, randomized trial comparing BioGlue and Vivostat for the control of alveolar air leak
E. Belcher, M. Dusmet, S. Jordan, G. Ladas, E. Lim, P. Goldstraw
The Journal of Thoracic and Cardiovascular Surgery 2010, Volume 140, Number 1; 32-38
Autologous fibrin sealant reduces the incidence of prolonged air leak and duration of chest tube drainage after lung volume reduction surgery
C. Moser, I. Opitz, W. Zhai, V. Rousson, E. W. Russi, W. Weder, D. Lardinois
The Journal of Thoracic and Cardiovascular Surgery 2008, Volume 136, Number 4; 843-849
The effect of autologous fibrin sealant (Vivostat) on morbidity after pulmonary Lobectomi – a prospective randomized, blinded study
A. Belboul, L. Dernevik, O. Aljassim, B. Skrbic, G. Rådberg, D. Roberts
European Journal of Cardio-thoracic Surgery 2004; 26: 1187–1191
A prospective randomized trial comparing homologous and autologous fibrin sealants for the control of alveolar air leak
B. Kılıç, E.Erşen, A. Demirkaya, H. Volkan Kara, N. Alizade, M. İşcan, K. Kaynak, A. Turna
European Journal of Thoracic Disease 2017; 9(9): 2915-2922
Autologous Fibrin sealant (Vivostat) in General Surgery Post interventional survey at three exemplary patients
J. Jacobs
Department of Thoracic Surgery and Thoracic Endoscopy; Essen, Germany
Autologer Fibrinkleber in der Thoraxchirurgie Machbarkeitsstudie in einen Zentrum
J. Jacobs, S. Welter, M. Altmayer, A. Breull, G. Stamatis
Presented at DACH 2010
Multiple wedge resection from Vivostat A/S on Vimeo.
Bronchial stump insufficiency from Vivostat A/S on Vimeo.
Vivostat® Fibrin Sealant is an autologous sealant that outperforms other fibrin sealants on parameters such as polymerisation, elasticity, adhesion and impact on tissue.
Vascular surgeons use Vivostat® Fibrin Sealant because of its exceptional elastic and adhesive performance on the graft surface and its ability to improve haemostasis. With these product characteristics it is possible to protect the anastomosis and reduce the risk of re-operations.
Further, the surgeon is able to use Vivostat® Co-Delivery to apply a given substance with the Vivostat® Fibrin Sealant.
Vascular surgery – abdominal aorta 2 (Vivostat) from Vivostat A/S on Vimeo.
Vascular surgery – Aortic diverticulum (Vivostat) from Vivostat A/S on Vimeo.
Vascular surgery – Carotid artery (Vivostat) from Vivostat A/S on Vimeo.
The combination of platelets and fibrin in Vivostat PRF® is unique.
Not only does the fibrin protect the platelets from proteolytic degradation,
it also ensures the slow release of growth factors over time and makes
the PRF®solution polymerize immediately upon application, which means
that the platelets stay where they are applied.
Learn more about the Vivostat PRF®product characteristics here.
The Vivostat®fully automated processing system secures a consistent, high number of platelets
extracted from the patient’s own blood. Learn more about the Vivostat® system here
Vivostat A/S also offers wound care specialists the flexible wound treatment, Vivostat®Wound Therapy, that combines Growth Factors, Antibiotics and Vagus Stimulation. Vivostat®Wound Therapy consists of 3 scientifically proven techniques that separately or in a combination can effectively combat non-healing wounds!
Use of autologous platelet-rich fibrin on hard-to-heal wound
P. Steenvoorde, L.P. van Doorn, C. Naves, J. Oskam
Journal of Wound Care 2008; 1 7 (2 ): 60-63
Our experience in the treatment of chronic ulcers using Vivostat® PRF®. Series of 10 cases
M. Fuertes, V. Velasco, G.E. Larrañagag, G. Peirona
Cir. plást. Iberolatinoam 2009; 35 (2): 141-148
Clinical Experience of Vivostat® Platelet Rich Fibrin (PRF®) in treatment of Diabetic foot ulcers
M. Löndahl
Presented at the 13eme Conference nationale des plaies et cicatrisations 2009
Comparative Study of two different treatment methods using autologous thrombocyte-fibrin treatment of diabetic foot ulcers
G. Larsson, M. Löndahl
Presented at Jubileumsriksstämman 2008
Growth factor and proteinase profile of Vivostat platelet-rich fibrin linked to tissue repair
M. S. Agren, K. Rasmussen, B. Pakkenberg & B. Jørgensen
Vox Sanguinis (2013); 107(1), 37-43
Autologes thrombozytenreiches Fibrin – eine neue Möglichkeit zur Wundtherapie bei komplizierten chronischen Wunden
K.P. Arenth, C. Schneider, D. Ockert
Wundtherapie bei komplizierten chronischen Wunden 2009
Selected case stories, Vivostat® platelet rich fibrin (PRF®) in the treatment of chronic wounds
B. Jørgensen, M. Löndahl,G. Larsson, H. Monberg
Published in the Swedish wound magazine “Sår” – March 2008
Vivostat PRF® for the treatment of hard to heal ischemic diabetic ulcer
P. Steenvoorde, L. van Doorn, J. Oskam
From the department of SurgeryRijnland Hospital Leiderdorp and the Rijnland Wound Clinic Leiderdorp, in the Netherlands
Use of autologous growth factors to heal chronic wounds
D. Sommer
Forum Sanitas – The Informative Medical Magazine 2008
Platelet Rich Fibrin (PRF) for hard to heal ulcers in patients with diabetic feet
C. Naves, P. Steenvoorde, L. Van Doorn
European Tissue Repair Society 2008
Autologus Platelet-Rich Fibrin for the treatment of hard to heal diabetic ulcers
L. van Doorn, P. Steenvoorde, J. Oskam
Noordwijkerhout 2007
Platelet Rich Fibrin seems to be a safe and effective treatment in diabetic patients with lower extremity fistula
Å. Asmundsson, M. Löndahl, I. Dupros, G. Larsson, P. Katzman
Skane University Hospital (Lund, SWEDEN)
Effects of locally applied autologous Platelet-Rich Fibrin® (PRF®) on split-thickness skin graft donor sites
P. Danielsen, B. Jørgensen, T. Karlsmark, L.N. Jørgensen, M. Ågren
Presented at EWMA 2010
Platelet gel applications in oral mucositis in CGVHD
A.S. Ferraro et al.
Presented at the European Hematology Association Congress 2008
Application of PLTs gel for the treatment of refractory chronic GvHD skin lesions
A. Picardi et al.
Presented at the meeting European Group for Blood and Marrow Transplantation
Tension free Primary Closure with Autologous Platelet Gel Versus VivostatTM for the Definitive Treatment of Chronic Sacrococcygeal Pilonidal Disease
Gipponi et al
In vivo 24: 583-590 (2010)
Autologes thrombozytenreiches Fibrin kombiniert mit vagaler Stimulation
T. Payrits et. al
Skriptum Kongressjournal, 12. Jahrestagung der Österreichischen gesellschaft für Wundbehandlung
10 April, 2010
Platelet Rich Fibrin seems to be a safe and effective treatment in diabetic patients with lower extremity fistula
M. Løndahl et. al
Platelet gel applications in oral Mucisitis in CGVHD
A.S. Ferraro et. al
13th Congress of the European Hematology Association
June 12-15, 2008
Platelet-released growth factors induce the antimicrobial peptide human beta-defensin-2 in primary keratinocytes
Bayer et. al
Experimental Dermatology, 2016, 25, 460–465
Treatment of foot wound from Vivostat A/S on Vimeo.
Perianal fistula treated with Vivostat PRF from Vivostat A/S on Vimeo.